ISO INTERNATIONAL STANDARD 10808 First edition 2010-12-15 Nanotechnologies Characterization of nanoparticles in inhalation exposure chambers for inhalation toxicity testing NanotechnologiesCaracterisation des nanoparticules dansles chambres d'inhalation par exposition pour les essais de toxicite par inhalation Reference number ISO 10808:2010(E) @ ISO 2010 yIHSunder ISO 10808:2010(E) PDF disclaimer This PDF file may contain embedded typefaces. In accordance with Adobe's licensing policy, this file may be printed or viewed but shall not be edited unless the typefaces which are embedded are licensed to and installed on the computer performing the editing. In accepts no liability in this area. Adobe is a trademark of Adobe Systems Incorporated. Details of the software products used to create this PDF file can be found in the General Info relative to the file; the PDF-creation the unlikely event that a problem relating to it is found, please inform the Central Secretariat at the address given below COPYRIGHT PROTECTED DOCUMENT ISO2010 All rights reserved. Unless otherwise specified, no part of this publication may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying and microfilm, without permission in writing from either isO at the address below or ISO's member body in the country of the requester. ISO copyright office Case postale 56 . CH-1211 Geneva 20 Tel. + 4122 749 01 11 Fax + 41 22 749 09 47 E-mail [email protected] Web www.iso.org Published in Switzerland @ ISO 2010 - All rights reserved I without license from IHS Not for Resale ISO 10808:2010(E) Contents Page Foreword IV Introductior 1 Scope 2 Normative references 3 Terms and definitions . 3.1 Particle measuring systems. 4 Test substance monitoring method 4.1 Principle 4.1.1 Exposure 4.1.2 Particle properties.. 4.2 Preparation of system.. 4.3 5 Specificmonitoringmethod.. 5.1 Requirements for number-based particle size distribution and mass concentration 5.2 Measurement of number-based particle size distribution .... 5.3 Massconcentrationmeasurement 5.4 Inhalation exposure chamber 6 Assessment of results 7 Testreport Annex A (informative) Example of nanoparticle characterization for inhalation toxicity testing .... Bibliography. Copyright International Organization frStandardizalion'ghts reserved ii from IHS Not for Resa